Kathryn Blake, PharmD
Center Director/Principal Research Scientist- Asthma
- Digital Devices For Adherence
- Pharmacogenomics
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Opportunities for Pharmacogenomics in Pediatrics: Prescribing Trends of Psychiatric Medications With Pharmacogenomic Implications at a Multistate Pediatric Health System; Journal of Pediatric Pharmacology and Therapeutics; (2025).
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Drivers of Bronchodilator Use in Bronchiolitis: Analyzing Treatment Trends From Pediatric Emergency Department Practices; Pediatric Emergency Care; (2025).
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Evaluation of the implementation of evidence-based pediatric asthma exacerbation treatments in a regional consortium of emergency medical Services Agencies; Journal of Asthma; (2024).
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Early Administration of Steroids in the Ambulance Setting: An聽Observational Design Trial (EASI-AS-ODT); Academic Emergency Medicine; (2024).
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Changes in Bronchiolitis Characteristics During the COVID-19 Pandemic: A Description of Pediatric Emergency Department Visits in a Community Hospital, 2019-2021; Clinical Pediatrics; (2024).
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Association of Sputum Eosinophilia With Easily Measured Type-2 Inflammatory Biomarkers in Untreated Mild Persistent Asthma; Journal of Allergy and Clinical Immunology in Practice; (2024).
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A Community-Guided Approach to Bronchiolitis: A Needs Assessment and Illness Perception Study; Journal of Patient Experience; (2024).
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Lack of awareness and knowledge of NHLBI 2020 Asthma Focused Updates; Journal of Allergy and Clinical Immunology in Practice; (2024).
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Rationale and design for a pragmatic randomized trial to assess gene-based prescribing for SSRIs in the treatment of depression; Clinical and Translational Science; (2024).
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Nationwide trends in hospitalization, medical costs, and mortality for asthma after introduction of biologics: A cross-sectional study in the United States; Journal of Managed Care and Specialty Pharmacy; (2023).
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Ethics Challenges in Pediatric Research; Journal of Pediatric Pharmacology and Therapeutics; (2023).
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Comprehension by Caregivers and Adolescents of Clinical Trial Information Delivered via Multimedia Video Versus Conventional Practice: Nonrandomized Controlled Trial; Jmir Pediatrics and Parenting; (2023).
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Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution; Clinical and Translational Science; (2023).
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Beginning to Address an Implementation Gap in Asthma: Clinicians' Views of Prescribing Reliever Budesonide-Formoterol Inhalers and SMART in the United States; Journal of Allergy and Clinical Immunology in Practice; (2023).
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A digital health application for managing pediatric asthma: Use and benefits; Informatics for Health and Social Care; (2023).
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A Call for the United States to Accelerate the Implementation of Reliever Combination Inhaled Corticosteroid-Formoterol Inhalers in Asthma; American Journal of Respiratory and Critical Care Medicine; (2023).
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Comprehension by Caregivers and Adolescents of Clinical Trial Information Delivered via Multimedia Video Versus Conventional Practice: Nonrandomized Controlled Trial (Preprint); Unknown Source; (2022).
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鈥淚t is kind of like a responsibility thing鈥: transitional challenges in asthma medication adherence among adolescents and young adults; Journal of Asthma; (2022).
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Best鈥搘orst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy; Implementation Science Communications; (2022).
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Biomarkers to Predict Response to Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists in Adolescents and Adults with Mild Persistent Asthma; Annals of the American Thoracic Society; (2022).
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Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators; Clinical and Translational Science; (2022).
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Multisite evaluation of institutional processes and implementation determinants for pharmacogenetic testing to guide antidepressant therapy; Clinical and Translational Science; (2022).
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The challenge of addressing obesity in people with poorly controlled asthma; Obesity Science and Practice; (2021).
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The 2020 focused updates to the NIH asthma management guidelines: Key points for pediatricians; Pediatrics; (2021).
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Telemedicine and adherence monitoring in children with asthma; Current Opinion in Pulmonary Medicine; (2021).
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Single Nucleotide Polymorphisms (SNPs) in PRKG1 & SPATA13 -AS1 are associated with bronchodilator response: A pilot study during acute asthma exacerbations in African American children; Pharmacogenetics and Genomics; (2021).
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Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma; Lancet Child and Adolescent Health; (2021).
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Opportunity for Genotype-Guided Prescribing Among Adult Patients in 11 US Health Systems; Clinical Pharmacology and Therapeutics; (2021).
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Key Considerations for Selecting a Genomic Decision Support Platform for Implementing Pharmacogenomics; Clinical Pharmacology and Therapeutics; (2021).
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Health-related quality of life and health utilities of mild, moderate, and severe asthma: Evidence from the medical expenditure panel survey; Journal of Asthma and Allergy; (2021).
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Geography, generalisability, and susceptibility in clinical trials; Lancet Respiratory Medicine; (2021).
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Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network; Genetics in Medicine; (2021).
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Ensuring access to albuterol in schools: From policy to implementation an official ATS/AANMA/ALA/NASN policy statement; American Journal of Respiratory and Critical Care Medicine; (2021).
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Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network (Genetics in Medicine, (2019), 21, 3, (743-747), 10.1038/s41436-018-0080-y); Genetics in Medicine; (2021).
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A Single Inhaler Combining a Corticosteroid and Long-Acting Beta-2 Agonist for Maintenance with Additional Doses for Reliever Therapy (SMART): Obstacles for Asthma Patients in the USA; Pediatric Allergy Immunology and Pulmonology; (2021).
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2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group; Journal of Allergy and Clinical Immunology; (2020).
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Considerations for the Child with Nonatopic Asthma; Pediatric Allergy Immunology and Pulmonology; (2020).
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Biomarkers of Type 2 Airway Inflammation as Predictors of Loss of Asthma Control During Step-Down Therapy for Well-Controlled Disease: The Long-Acting Beta-Agonist Step-Down Study (LASST); Journal of Allergy and Clinical Immunology in Practice; (2020).
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Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients; JAMA Network Open; (2020).
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Methods and implementation of a pediatric asthma pharmacogenomic study in the emergency department setting; Pharmacogenetics and Genomics; (2020).
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Medical costs and productivity loss due to mild, moderate, and severe asthma in the United States; Journal of Asthma and Allergy; (2020).
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Knowledge and attitudes on pharmacogenetics among pediatricians; Journal of Human Genetics; (2020).
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Early administration of steroids in the ambulance setting: Protocol for a type I hybrid effectiveness-implementation trial with a stepped wedge design; Contemporary Clinical Trials; (2020).
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Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network (Genetics in Medicine, (2019), 21, 3, (743-747), 10.1038/s41436-018-0080-y); Genetics in Medicine; (2020).
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Emergency Medical Services Administration of Systemic Corticosteroids for Pediatric Asthma: A Statewide Study of Emergency Department Outcomes; Academic Emergency Medicine; (2019).
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Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation; Journal of Allergy and Clinical Immunology in Practice; (2019).
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Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network; Genetics in Medicine; (2019).
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Novel Implementation of Genotype-Guided Proton Pump Inhibitor Medication Therapy in Children: A Pilot, Randomized, Multisite Pragmatic Trial; Clinical and Translational Science; (2019).
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Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing; Genetics in Medicine; (2019).
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Mometasone or tiotropium in mild asthma with a low sputum eosinophil level; New England Journal of Medicine; (2019).
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Genotype tailored treatment of mild symptomatic acid reflux in children with uncontrolled asthma (GenARA): Rationale and methods; Contemporary Clinical Trials; (2019).
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Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network (Genetics in Medicine, (2019), 21, 3, (743-747), 10.1038/s41436-018-0080-y); Genetics in Medicine; (2019).
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Step-up therapy in black children and adults with poorly controlled asthma; New England Journal of Medicine; (2019).
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Asthma: moving toward a global children's charter; Lancet Respiratory Medicine; (2019).
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Asthma Guidelines Priority Topics: Intermittent Inhaled Corticosteroid Therapy and Inhaled Corticosteroids with Long Acting Beta-Agonists as Reliever Therapy; Pediatric Allergy Immunology and Pulmonology; (2019).
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Adapting clinical trial design to maintain meaningful outcomes during a multicenter asthma trial in the precision medicine era; Contemporary Clinical Trials; (2019).
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Postoperative Pain and 14-Day Recovery in Children Undergoing Adenotonsillectomy: Low Thermal Damage Device Versus Electrosurgery; Ear Nose and Throat Journal; (2019).
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Association of inhaled corticosteroids and long-acting 尾-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma a systematic review and meta-analysis; JAMA Journal of the American Medical Association; (2018).
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Association of inhaled corticosteroids and long-acting muscarinic antagonists with asthma control in patients with uncontrolled, persistent asthma a systematic review and meta-analysis; JAMA Journal of the American Medical Association; (2018).
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Asthma Guidelines Priority Topic: Long-Acting Anti-Muscarinic Agents in Asthma Management as Add-On to Inhaled Corticosteroids; Pediatric Allergy Immunology and Pulmonology; (2018).
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Temporary increased dose of inhaled corticosteroids in yellow zone, does it work?; Pediatric Allergy Immunology and Pulmonology; (2018).
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Step-Down Therapy for Asthma Well Controlled on Inhaled Corticosteroid and Long-Acting Beta-Agonist: A Randomized Clinical Trial; Journal of Allergy and Clinical Immunology in Practice; (2018).
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Quintupling inhaled glucocorticoids to prevent childhood asthma exacerbations; New England Journal of Medicine; (2018).
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Improving the affordability of prescription medications for people with chronic respiratory disease an official American thoracic society policy statement; American Journal of Respiratory and Critical Care Medicine; (2018).
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Glutathione and arginine levels: Predictors for acetaminophen-associated asthma exacerbation?; Journal of Allergy and Clinical Immunology; (2018).
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Asthma Guidelines from the National Asthma Education and Prevention Program: Where Are We Now?; Pediatric Allergy Immunology and Pulmonology; (2018).
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The IGNITE Pharmacogenetics Working Group: An Opportunity for Building Evidence with Pharmacogenetic Implementation in a Real-World Setting; Clinical and Translational Science; (2017).
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Personalized Medicine in Preschool Children with Asthma; Pediatric Allergy Immunology and Pulmonology; (2017).
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Inhaling Essential Oils: Purported Benefits and Harms; Pediatric Allergy Immunology and Pulmonology; (2017).
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Improving adherence to asthma medications: Current knowledge and future perspectives; Current Opinion in Pulmonary Medicine; (2017).
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Acetaminophen and Asthma in Children: Association or Causality?; Pediatric Allergy Immunology and Pulmonology; (2017).
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A cognitive approach for design of a multimedia informed consent video and website in pediatric research; Journal of Biomedical Informatics; (2017).
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Macrolides for Acute Wheezing Episodes in Preschool Children; Pediatric Allergy Immunology and Pulmonology; (2016).
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Individualized therapy for persistent asthma in young children; Journal of Allergy and Clinical Immunology; (2016).
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Acetaminophen versus Ibuprofen in young children with Mild Persistent Asthma; New England Journal of Medicine; (2016).
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Mepolizumab: A New Class of Treatment for Adolescents with Severe Persistent Asthma; Pediatric Allergy Immunology and Pulmonology; (2016).
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Management of Acute Cough in Children: Where Do We Go from Here?; Pediatric Allergy Immunology and Pulmonology; (2016).
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Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: A randomized clinical trial; JAMA Journal of the American Medical Association; (2015).
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Adolescent Asthma Pharmacotherapy in a State of Flux; Pediatric Allergy Immunology and Pulmonology; (2015).
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Vitamin D and Asthma: Association, Causality, or Intervention?; Pediatric Allergy Immunology and Pulmonology; (2015).
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Use of mobile devices and the internet for multimedia informed consent delivery and data entry in a pediatric asthma trial: Study design and rationale; Contemporary Clinical Trials; (2015).
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Updated Guidelines on Allergic Rhinitis - Anything New?; Pediatric Allergy Immunology and Pulmonology; (2015).
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Pharmacogenomics of long-acting 尾2-agonists; Expert Opinion on Drug Metabolism and Toxicology; (2015).
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Nonprescription epinephrine metered-dose inhaler: To be or not to be; Pediatric Allergy Immunology and Pulmonology; (2014).
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New and evolving therapies for cystic fibrosis patients; Pediatric Allergy Immunology and Pulmonology; (2014).
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Inhaled mannitol for children with cystic fibrosis: Why it missed the mark for FDA approval; Pediatric Allergy Immunology and Pulmonology; (2014).
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Association of CYP2C19 polymorphisms and lansoprazole-associated respiratory adverse effects in children; Journal of Pediatrics; (2013).
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Pharmacogenetics of asthma controller treatment; Pharmacogenomics Journal; (2013).
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Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): Rationale and methods; Contemporary Clinical Trials; (2013).
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Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16; Pulmonary Pharmacology and Therapeutics; (2013).
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Gastroesophageal reflux disease and childhood asthma; Current Opinion in Pulmonary Medicine; (2013).
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Considerations for care: Management of asthma in the child with sickle cell disease; Pediatric Allergy Immunology and Pulmonology; (2013).
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Chiral switch drugs for asthma and allergies: True benefit or marketing hype; Pediatric Allergy Immunology and Pulmonology; (2013).
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A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics; Pharmacogenomics Journal; (2013).
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Role of biomarkers in understanding and treating children with asthma: Towards personalized care; Pharmacogenomics and Personalized Medicine; (2013).
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Small airway targeted therapy in pediatric Asthma: Are we there yet?; Pediatric Allergy Immunology and Pulmonology; (2013).
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Principles of Lung Therapeutics; Nursing Care in Pediatric Respiratory Disease; (2013).
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Does use of inhaled corticosteroid for management of asthma in children make them shorter adults?; Pediatric Allergy Immunology and Pulmonology; (2013).
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Sickle-cell trait and atopic and inflammatory disease in children; Pediatric Allergy Immunology and Pulmonology; (2013).
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Lansoprazole for children with poorly controlled asthma a randomized controlled trial; JAMA; (2012).
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Bioavailability of inhaled fluticasone propionate via chambers/masks in young children; European Respiratory Journal; (2012).
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Pharmacogenomic testing in the asthma clinic: Will inhaled corticosteroids lead the way?; Pediatric Allergy Immunology and Pulmonology; (2012).
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Treatment of pediatric asthma with proton pump inhibitors: Three strikes, game over; Pediatric Allergy Immunology and Pulmonology; (2012).
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Management of wheezing in preschool children; Pediatric Allergy Immunology and Pulmonology; (2012).
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Comparison of inhaled corticosteroids: What you need to know in choosing a product; Pediatric Allergy Immunology and Pulmonology; (2011).
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As needed use of inhaled corticosteroids for management of mild persistent asthma in children; Pediatric Allergy Immunology and Pulmonology; (2011).
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Asthma in sickle cell disease: Implications for treatment; Anemia; (2011).
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10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): A multicentre randomised trial; Lancet; (2010).
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Pharmacogenetics of asthma; Current Opinion in Pulmonary Medicine; (2009).
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Efficacy of esomeprazole for treatment of poorly controlled asthma; New England Journal of Medicine; (2009).
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EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency; Journal of Cystic Fibrosis; (2009).
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The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: Effectiveness of early intervention with budesonide in mild persistent asthma; Journal of Allergy and Clinical Immunology; (2008).
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Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma; Chest; (2008).
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Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma; Chest; (2006).
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Reply [4]; Journal of Pediatrics; (2006).
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The C523A 尾2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans; Journal of Asthma; (2006).
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Review of guidelines and the literature in the treatment of acute bronchospasm in asthma; Pharmacotherapy; (2006).
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Efficacy and safety of inhaled fluticasone propionate chlorofluorocarbon in 2- to 4-year-old patients with asthma: Results of a double-blind, placebo-controlled study; Annals of Allergy Asthma and Immunology; (2006).
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Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosis; Journal of Pediatrics; (2006).
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Safety of budesonide inhalation suspension in infants aged six to twelve months with mild to moderate persistent asthma or recurrent wheeze; Journal of Pediatrics; (2005).
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Impact of inadequately controlled asthma: A need for targeted therapy?; Journal of Clinical Pharmacy and Therapeutics; (2004).
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Fluticasone propionate and salmeterol administered via Diskus compared with salmeterol or fluticasone propionate alone in patients suboptimally controlled with short-acting 尾2-agonists; Annals of Allergy Asthma and Immunology; (2004).
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Lack of effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary-adrenal axis in 2- and 3-year-old patients; Pediatrics; (2003).
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Effect of Montelukast on Time-Course of Exhaled Nitric Oxide in Asthma: Influence of LTC4 Synthase A-444C Polymorphism; Pediatric Pulmonology; (2003).
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Early intervention with budesonide in mild persistent asthma: A randomised, double-blind trial; Lancet; (2003).
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Exhaled nitric oxide concentrations: Online versus offline values in healthy children; Pediatric Pulmonology; (2002).
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Effect of 尾2-agonist treatment and spirometry on exhaled nitric oxide in healthy children and children with asthma; Pediatric Pulmonology; (2002).
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Plastic bottles as spacers for a pressurized metered-dose inhaler: In vitro characteristics; West Indian Medical Journal; (2001).
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Management of allergic rhinitis and sinusitis; Journal of Pharmacy Practice; (2001).
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Introduction: Pulmonary medicine II; Journal of Pharmacy Practice; (2001).
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Introduction: Pulmonary medicine; Journal of Pharmacy Practice; (2001).
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Drug treatment of airway inflammation in asthma; Pharmacotherapy; (2001).
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Drug therapy approaches in the treatment of acute severe asthma in hospitalised children; Paediatric Drugs; (2001).
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Exhaled nitric oxide as an indicator of severity of asthmatic inflammation; Pediatric Emergency Care; (2000).
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Erratum: Montelukast in asthma management (Annals of Pharmacotherapy (1999) 33 (1299-1314)); Annals of Pharmacotherapy; (2000).
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FE(NO): Relationship to exhalation rates and online versus bag collection in healthy adolescents; American Journal of Respiratory and Critical Care Medicine; (2000).
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Exhaled nitric oxide measurements in childhood asthma: Techniques and interpretation; Pediatric Pulmonology; (1999).
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Montelukast dose selection in 6- to 14-year-olds: Comparison of single-dose pharmacokinetics in children and adults; Journal of Clinical Pharmacology; (1999).
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Montelukast: Data from clinical trials in the management of asthma; Annals of Pharmacotherapy; (1999).
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Prevention of exercise-induced bronchospasm in pediatric asthma patients: A comparison of salmeterol powder with albuterol; Annals of Allergy Asthma and Immunology; (1999).
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Measurement of pulmonary exhaled nitric oxide: Relationship to exhalation rates and inline versus bag collection techniques; Critical Care Medicine; (1998).
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Asthma management: What you need to know; American Druggist; (1998).
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Manual volume-controlled ventilation in preterm neonates compared to ventilation via self-inflating resuscitator; Respiratory Care; (1996).
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Theophylline attenuation of airway responses to allergen: Comparison with cromolyn metered-dose inhaler; Journal of Allergy and Clinical Immunology; (1995).
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Reply; Journal of Allergy and Clinical Immunology; (1995).
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Salmeterol: Its place in asthma management; Annals of Pharmacotherapy; (1994).
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Bioequivalence of a generic slow-release theophylline tablet in children; Journal of Pediatrics; (1994).
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The Effect of Short鈥怲erm Administration of Theophylline on Erythropoietin Levels in Healthy Adults; Pharmacotherapy the Journal of Human Pharmacology and Drug Therapy; (1994).
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Relative amount of albuterol delivered to lung receptors from a metered- dose inhaler and nebulizer solution; Bioassay by histamine bronchoprovocation; Chest; (1992).
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Regularly scheduled versus as-needed use of inhaled 尾 agonists in the treatment of asthma; Clinical Pharmacy; (1992).
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Factors affecting clinical response to asthma treatment; Journal of the American Osteopathic Association; (1992).
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Evaluation of a generic albuterol metered-dose inhaler: Importance of priming the MDI; Annals of Allergy; (1992).
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Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice; Annals of Emergency Medicine; (1988).
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Death of a child associated with multiple overdoses of acetaminophen; Clinical Pharmacy; (1988).